
Inositol for Fertility: Science and Supplementation
This article breaks down the roles of Myo- and D-Chiro-Inositol in supporting ovulation and improving fertility outcomes in women with PCOS.
Read MoreA deep dive into how PCOS affects ovulation, diagnostic markers, and interventions that improve chances of conception.
Polycystic Ovary Syndrome (PCOS) is one of the leading causes of anovulatory infertility. The condition disrupts the hypothalamic-pituitary-ovarian (HPO) axis, leading to irregular or absent ovulation. Elevated luteinizing hormone (LH) levels and hyperandrogenism impair follicular maturation, often causing multiple immature follicles to develop without a dominant follicle reaching ovulation.
PCOS patients experiencing ovulatory dysfunction
Women with PCOS who are overweight or obese
Improvement in ovulation rate with lifestyle changes
Irregular menstrual cycles (typically >35 days), absence of cervical mucus changes, and lack of mid-cycle LH surge are clinical indicators. Ultrasound often shows a 'string of pearls' pattern on ovaries, and serum progesterone <3 ng/mL in the luteal phase confirms anovulation.
Several first-line and adjunctive therapies are used to trigger ovulation:
Weight loss of 5–10% in overweight women can restore spontaneous ovulation
Clomiphene Citrate or Letrozole are commonly prescribed ovulation inducers
Metformin improves insulin sensitivity, indirectly restoring ovulation in some cases
Gonadotropin therapy may be considered in resistant cases under specialist supervision
In addition to medical support, fertility-focused individuals with PCOS benefit from monitoring their ovulation through:
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