
PCOS and Macronutrients: What Science Says
A science-backed guide to how carbohydrates, fats, and proteins influence hormonal balance and insulin sensitivity in PCOS.
Read MoreLearn how inflammation contributes to PCOS and how specific dietary patterns can reduce it to improve hormonal and metabolic health.
Chronic low-grade inflammation is a hallmark of PCOS, contributing to insulin resistance, ovulatory dysfunction, and elevated androgen levels. Elevated levels of markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and TNF-α have been consistently observed in women with PCOS. These inflammatory pathways not only worsen metabolic disturbances but also increase cardiovascular risk. Fortunately, diet plays a significant role in modulating this inflammation.
Women with PCOS show elevated CRP levels
Improvement in insulin sensitivity on anti-inflammatory diets
Sustained reduction in IL-6 on Mediterranean diet (Di Lorenzo et al., 2022)
Understanding how systemic inflammation worsens PCOS symptoms helps shape an effective dietary strategy.
Triggers androgen production and ovarian dysfunction
Damages follicular development and increases insulin resistance
Contributes to cardiovascular risk, a common long-term concern in PCOS
These foods help reduce systemic inflammation and support hormone balance in PCOS.
Rich in omega-3 fatty acids (EPA/DHA) which reduce inflammatory cytokines
Contain polyphenols and antioxidants that fight oxidative stress
High in anthocyanins that lower CRP and IL-6 levels
Adopting these eating patterns has shown benefits in reducing inflammation and PCOS symptoms:
Here’s a sample weekly plan that targets inflammation using evidence-based PCOS nutrition strategies:
Day 1: Grilled salmon + quinoa + spinach salad
Day 2: Chickpea stew with turmeric + steamed broccoli
Day 3: Lentil soup + mixed greens + avocado
Day 4: Grilled chicken + sweet potato + sautéed kale
Day 5: Tofu stir-fry + brown rice + red bell peppers
Day 6: Sardines on whole-grain toast + arugula salad
Day 7: Mushroom curry + cauliflower rice + cucumber raita
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