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Metformin for PCOS: Insulin Control and Hormonal Balance

An in-depth look at how metformin supports insulin sensitivity and menstrual health in PCOS patients.

What You'll Learn

How metformin improves insulin resistance in PCOS
Positive impacts on menstrual regularity and ovulation
Potential side effects and monitoring requirements
Guidelines for safe, doctor-prescribed use

How Metformin Works in PCOS

Metformin, a GLP-1 agonist originally developed for type 2 diabetes, reduces hepatic glucose production and improves peripheral insulin sensitivity. In PCOS, elevated insulin contributes to androgen overproduction—metformin helps break this cycle.

Clinical Insights

40–60%

Normalization of menstrual cycles with metformin

2–4 kg

Average weight loss in lean PCOS patients

15–25%

Reduction in fasting insulin levels

Usage & Monitoring

Follow this protocol under a physician’s supervision:

Diagnostic Process

Start at 500 mg daily with food; increase gradually to 1,500–2,000 mg/day

Monitor kidney and liver function periodically

Be alert for GI side effects like nausea or diarrhea

Take with meals to ease stomach discomfort

Benefits & Precautions

Metformin can:

Restore ovulation

Stimulates regular periods in many women

Improve metabolic status

Lowers insulin and supports weight management

Cause GI upset

Side effects are common but transient

Important Disclaimer

⚠️ Metformin should **only** be taken under the advice and dosage plan of a qualified physician. Self-medication may lead to complications.

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