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Letrozole vs. Clomiphene: Comparing Ovulation Inducers
Detailed comparison of Letrozole and Clomiphene citrate in PCOS fertility treatment, including success rates and safety.
What You'll Learn
- Mechanism differences between Letrozole & Clomiphene
- Clinical success in PCOS-related infertility
- Benefits, side effects, and patient selection
- Supervised prescribing and monitoring protocols
Letrozole: First-Line Ovulation Aid
Letrozole suppresses aromatase, reducing estrogen and boosting FSH release. Multiple studies show it outperforms Clomiphene in achieving live births in PCOS patients.
Clinical Outcomes
27%
Live birth rate with Letrozole vs. 19% with Clomiphene
21%
Multiple pregnancy risk with Clomiphene vs. 3.6% with Letrozole
4–5%
Ovarian hyperstimulation incidence
Medication Comparison
Side-by-side overview:
Letrozole
- Dosage: 2.5–7.5 mg/day on days 3–7
- Fewer side effects and thinner endometrium
- Lower multiple pregnancy rates
Clomiphene Citrate
- Dosage: 50–150 mg/day on days 3–7
- Can cause hot flashes and mood changes
- Higher risk of multiple gestation
Professional Use Guidelines
Administer under medical supervision:
Diagnostic Process
1
Track ovulation via ultrasound or OPK
2
Limit to 3–6 cycles to reduce resistance
3
Switch protocol if no response by cycle 3
4
Monitor for ovarian enlargement and vision changes
Safety Notice
💡 Letrozole and Clomiphene should be taken **only with prescription and monitoring** by a fertility specialist.
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